The Colts won the AFC South in 2010 making their 9th straight playoff appearance.

Colts Lost in round one of the playoffs to the Jets 16-17 by a last second field goal.

Preseason 0-4

Week
Date
Time
Channel
Opponent
Score
W/L
1
08/15/10
1:00 pm
WTTV 4
San Fransisco
17-37
L
2
08/19/10
7:30 pm
WTTV 4
at Buffalo
21-34
L
3
08/26/10
8:30 pm
ESPN
at Green Bay
24-59
L
4
09/02/10
7:00 pm
WTTV 4
Cincinnati
28-30
L

Regular Season 10-6

Week
Date
Time
Channel
Opponent
Score
W/L
1
09/12/10
1:00 pm
WISH 8
at Houston
24-34
L
2
09/19/10
8:20 pm
WTHR 13
N.Y. Giants
38-14
W
3
09/26/10
4:15 pm
WISH 8
at Denver
27-13
W
4
10/03/10
4:05 pm
WISH 8
at Jacksonville
28-31
L
5
10/10/10
1:00 pm
WISH 8
Kansas City
19-9
W
6
10/17/10
8:20 pm
WTHR 13
at Washington
27-24
W
7
BYE
BYE
BYE
BYE
-
-
8
11/01/10
8:30 pm
ESPN
Houston
30-17
W
9
11/07/10
4:15 pm
WISH 8
at Philadelphia
24-26
L
10
11/14/10
1:00 pm
WISH 8
Cincinnati
23-17
W
11
11/21/10
4:15 pm
WISH 8
at New England
31-28
L
12
11/28/10
8:20 pm
WTHR 13
San Diego
14-36
L
13
12/05/10
4:15 pm
WXIN 59
Dallas
35-38
L
14
12/09/10
8:20 pm
NFL-N
at Tennessee
30-28
W
15
12/19/10
1:00 pm
WISH 8
Jacksonville
34-24
W
16
12/26/10
4:05 pm
WISH 8
at Oakland
31-26
W
17
01/02/11
1:00 pm
WISH 8
Tennessee
23-20
W